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Effects of Stress

Aging and Stress
Chis Woolsten, MS

At any age, stress is a part of life. Young and old alike have to face difficult situations and overcome obstacles. While young adults struggle to establish a career, achieve financial security, or juggle work and family demands, older people may face failing health, dwindling finances, outliving loved ones -- or simply the challenges of retaining their independence. Unfortunately, the body's natural defenses against stress gradually break down with age. But you don't have to give in to stress just because you're no longer young.

The stress alarm

Stress comes in two basic flavors, physical and emotional -- and both can be especially taxing for older people. The impacts of physical stress are clear. As people reach old age, wounds heal more slowly and colds become harder to shake. A 75-year-old heart can be slow to respond to the demands of exercise. When an 80-year-old walks into a chilly room, it will take an extra-long time for her body temperature to adjust.

Emotional stress is more subtle, but if it's chronic, the eventual consequences can be as harmful. At any age, stressed-out brains sound an alarm that releases potentially harmful hormones such as cortisol and adrenaline. Ideally, the brain turns down the alarm when stress hormones get too high.

Stress hormones provide energy and focus in the short term, but too much stress over too many years can throw a person's system off-balance. Overloads of stress hormones have been linked to many health problems, including heart disease, high blood pressure, and weakened immune function. For older people already at heightened risk for these illnesses, managing stress is particularly important.

Over time, the brain can slowly lose its skills at regulating hormone levels. As a result, older people who feel worried or anxious tend to produce larger amounts of stress hormones, and the alarm doesn't shut down as quickly. According to a study published in the journal Psychoneuroendocrinology, women are especially susceptible to an overload of stress hormones as they age. The study found that the impact of age on cortisol levels is nearly three times stronger for women than for men.

The flow of stress hormones can be especially hard on older brains in general. According to a report from the University of California at San Francisco, extra cortisol over the years can damage the hippocampus, a part of the brain that's crucial for storing and retrieving memories. Several studies have found that high cortisol goes hand in hand with poor memory, so we might be able to chalk up certain "senior moments" to stress.

Years of emotional distress may even increase the risk of Alzheimer's disease. A five-year study of nearly 800 priests and nuns published in the journal Neurology highlighted this potential hazard. The subjects who reported the most stress were twice as likely as the least-stressed subjects to develop the disease.

Speeding up the clock

Stress doesn't just make a person feel older. In a very real sense, it can speed up aging. A study published in the Proceedings of the National Academy of Sciences found that stress can add years to the age of individual immune system cells. The study focused on telomeres, caps on the end of chromosomes. Whenever a cell divides, the telomeres in that cell get a little shorter and a little more time runs off the clock. When the telomere becomes too short, time runs out: The cell can no longer divide or replenish itself. This is a key process of aging, and it's one of the reasons humans can't live forever.

Researchers checked both the telomeres and the stress levels of 58 healthy premenopausal women. The stunning result: On average, the immune system cells of highly stressed women had aged by an extra 10 years. The study didn't explain how stress adds years to cells making up the immune system. As the study authors write, "the exact mechanisms that connect the mind to the cell are unknown." Researchers do have a not-very-surprising theory, though: Stress hormones could be somehow shortening telomeres and cutting the life span of cells.

Stress management: The real fountain of youth?

The good news is that we can put what we know about stress and aging to work for us. Learn to manage and reduce your stress load and you have a better chance to live a long, healthy life.

Maintaining a positive outlook is one key -- a study by Yale University found that people who feel good about themselves as they get older live about seven and a half years longer than "glass half empty" types. Researchers say the people with more positive attitudes may also deal with stress better and have a stronger will to live.

Staying close to friends and family is an excellent way to cut down on stress. As reported by the American Psychological Association, social support can help prevent stress and stress-related diseases. The benefits of friends and family can be especially striking for seniors. An article published in the American Journal of Health Promotion notes that social support can slow down the flow of stress hormones in seniors and, not coincidentally, increase longevity. Other studies have found that social interactions can help older people stay mentally sharp and may reduce the risk of Alzheimer's.


12 Ways Stress Negatively Affects Your Brain
Deane Alban


Some brain-related stress symptoms, like memory loss, brain fog, anxiety, and worry, will be obvious to you, but most of the effects of stress discussed below are “behind the scenes.” When stress becomes chronic, it changes your brain down to the level of your DNA. You won’t notice these changes while they’re happening, but you will notice the side effects … eventually.

1. Stress Creates Free Radicals That Kill Brain Cells

Cortisol creates a surplus of the neurotransmitter glutamate. While glutamate is a necessary and important brain chemical, in excess it turns against your brain and becomes a neurotoxin. Glutamate creates free radicals — unattached oxygen molecules — that attack brain cells in much the same way that oxygen attacks metal, causing it to rust. Free radicals actually punch holes in brain cell walls, causing them to rupture and die. Stress also indirectly contributes to other lifestyle habits that create more free radicals. If stress causes you to lose sleep, eat junk food, drink too much alcohol, or smoke cigarettes to cope, know that these unhealthy habits are adding to your free radical load.

2. Stress Makes You Forgetful and Emotional

Memory problems may be one of the first signs of stress that you’ll notice. Misplaced keys and forgotten appointments have you scrambling, further adding to your stress. If you find that all this stress is making you more emotional too, there’s a physiological reason for this. Studies show that when you’re stressed, electrical signals in the brain associated with factual memories weaken, while areas in the brain associated with emotions strengthen.

3. Stress Creates a Vicious Cycle of Fear and Anxiety

Stress actually fortifies an area of your brain called the amygdala. This is your brain’s fear center. Stress increases the size, activity level, and number of neural connections in this part of the brain. This makes you more fearful, causing a vicious cycle of even more fear and stress.

4. Stress Halts the Production of New Brain Cells

Every day you lose brain cells, but every day also you have the opportunity to create new ones. Brain-derived neurotrophic factor (BDNF) is a protein that’s integral in keeping existing brain cells healthy and in stimulating new brain cell formation. It’s often likened to fertilizer for the brain. BDNF can offset the negative effects of stress on the brain. But cortisol halts the production of BDNF, resulting in fewer new brain cells being formed. Lowered levels of BDNF are associated with brain-related conditions including depression, obsessive-compulsive disorder, schizophrenia, dementia, and Alzheimer’s disease.

5. Stress Depletes Critical Neurotransmitters

Your brain cells communicate via chemicals called neurotransmitters. Constant stress reduces levels of critical neurotransmitters, especially serotonin and dopamine. Low levels of either of these neurotransmitters can leave you depressed and more prone to addictions. Serotonin is dubbed the “happy molecule.” It plays a large role in mood, learning, appetite control, and sleep. Women low in serotonin are prone to depression, anxiety, and binge eating. Men, on the other hand, are more prone to alcoholism, ADHD, and impulse control disorders. Dopamine is known as the “motivation molecule.” It’s in charge of your pleasure-reward system. Too little dopamine can leave you unfocused, unmotivated, lethargic, and depressed. People low in this brain chemical often use caffeine, sugar, alcohol, and illicit drugs to temporarily boost their dopamine levels. Serotonin-based depression is characterized by anxiety and irritability, while dopamine-based depression expresses itself as lethargy and lack of enjoyment of life.

6. Stress Puts You at Greater Risk for Mental Illnesses of All Kinds

Recent research has discovered physical differences in the brains of people with stress disorders. Chronic stress puts you at increased risk for developing a variety of mental illnesses, including anxiety and panic disorders, depression, PTSD, schizophrenia, bipolar disorder, drug addiction, and alcoholism.

7. Stress Makes You Stupid

Stress can cause your brain to seize up at the worst possible times — exams, job interviews, and public speaking come to mind. This is actually a survival mechanism. If you’re faced with a life and death situation, instinct and subconscious impulse overwhelm rational thought and reasoning. This might keep you from being killed in an encounter with a tiger, but, in modern life, this is rarely helpful. Stress impairs your memory and makes you bad at making decisions. It negatively impacts virtually every cognitive skill you rely on to get through the day, including your ability to pay attention, remember, solve problems, make decisions, and think critically.

8. Stress Shrinks Your Brain

Stress can measurably shrink your brain. Cortisol can kill, shrink, and stop the generation of new neurons in the hippocampus, the part of your brain that stores memories. The hippocampus is critical for learning, memory and emotional regulation, as well as shutting off the stress response after a stressful event is over. Stress also shrinks the prefrontal cortex. This negatively affects decision making, working memory, and impulse control.

9. Stress Lets Toxins into Your Brain

Your brain is highly sensitive to toxins of every kind. The blood-brain barrier is a group of highly specialized cells that act as your brain’s gatekeeper. This semi-permeable filter protects the brain from harmful substances, while letting needed nutrients into the brain. Stress makes the blood-brain barrier more permeable, in effect making it leaky. This lets substances into the brain that you don’t want there — pathogens, heavy metals, chemicals, and neurotoxins of all kinds. Clearly, this is not desirable.

10. Stress Increases Your Risk of Dementia and Alzheimer’s

One of the most worrying effects of stress on the brain is that it increases your risk for dementia and Alzheimer’s. Being diagnosed with Alzheimer’s disease is now the #1 health fear of American adults. Alzheimer’s is also the sixth leading cause of death. One in three US seniors will die with Alzheimer’s or other forms of dementia. And it’s the most expensive disease in the country. There is no simple “magic bullet” to prevent Alzheimer’s. Common sense advice includes eating a healthy diet low in sugar and high in brain-healthy fats, getting physical exercise, not smoking, staying mentally active, avoiding toxic metal exposure, and minimizing stress. It’s been found that stress, particularly stress that occurs in midlife, increases your risk of Alzheimer’s. Mid-life occurrence of anxiety, jealousy, and moodiness doubles your risk of developing Alzheimer’s. Chronic stress and elevated cortisol contributes to dementia in the elderly and hastens its progression.

11. Stress Causes Brain Cells to Commit Suicide

Stress leads to premature aging on a cellular level, causing cells in both your body and your brain to commit suicide prematurely. To understand how this happens, we need to take a look at a part of your chromosomes called telomeres. You may recall from high school biology that when a cell divides, it passes on the genetic material to the new cell via chromosomes. Telomeres are protective endcaps on our chromosomes similar to the plastic tips on shoelaces. Every time a cell divides, the telomeres get a little shorter. When they reach a critically shortened length, they tell the cell to stop dividing, acting as a built-in suicide switch. Subsequently, the cell dies. Shortened telomeres lead to the atrophy of brain cells, while longer telomere length leads to the production of new brain cells. Telomere length may be the most important indicator of biological age and disease risk. Some researchers believe it’s a better predictor of your risk for age-related diseases like Alzheimer’s, heart disease, diabetes, and cancer than conventional diagnostic tools.

12. Stress Contributes to Brain Inflammation and Depression

A little-known fact is that the brain has its own immune system. Special immune cells called microglia protect the brain and spinal cord from infections and toxins. Unfortunately, a microglial cell has no on or off switch, so once it is activated, it creates inflammation for the rest of its lifespan. Chronic stress is one of the factors that increases the risk of activating your microglia, thus producing brain inflammation. It’s generally believed that depression is caused by serotonin deficiency, but there’s a growing body of evidence that brain inflammation may be the root cause of depression instead. This theory is called the “cytokine model of depression.” Activated microglia produce cytokines — proteins that turn on the inflammation response in the brain. Cytokine production is linked to depression, including major depressive disorder and increased thoughts of suicide. It’s also associated with anxiety, memory loss, and inability to concentrate, as well as some serious mental disorders such as schizophrenia, Parkinson’s, and Alzheimer’s.

How Stress Destroys Happiness

On top of all that …stress destroys your happiness and peace of mind. It wears you down mentally and emotionally and saps the joy from life. Some side effects of stress that negatively impact your overall mental outlook include:

  • excessive worry and fear
  • anger and frustration
  • impatience with self and others
  • mood swings, crying spells, or suicidal thoughts
  • insomnia, nightmares, disturbing dreams
  • trouble concentrating and learning new information
  • racing thoughts and nervousness
  • forgetfulness and mental confusion
  • difficulty in making decisions
  • feeling overwhelmed
  • irritability and overreaction to petty annoyances
  • excessive defensiveness or suspicion
  • increased smoking, alcohol or drug use, gambling, or impulse buying

In short, chronic stress leads to a bleak mental health outcome. But there is plenty you can do to reduce or respond more effectively to stress in your life.

6 Simple Steps to Protect Your Brain from Stress

Stress is an unavoidable part of life, but minimizing stress and protecting your brain against its effects is easier than you might think.

1. Eat antioxidant-rich foods

Stop free radical damage by eating a diet high in antioxidant-rich foods like fruits, vegetables, dark chocolate, and green tea.

2. Exercise daily

Increase levels of brain-boosting BDNF by getting daily physical exercise. Exercise doesn’t have to be strenuous. Walking is excellent. So are exercises with a strong mind-body connection like yoga, tai chi, and qi gong.

3. Meditate

Start a daily meditation practice. Meditation not only reduces stress, it’s also a proven way to keep your brain young by keeping telomeres long. Meditation is also the best tool for learning how to master your thoughts. Stress does not come from events in your life as much as it comes from your thoughts — your automatic negative reactions and cognitive distortions — about these events.

4. Use a relaxation technique

Try one of the many mind-body relaxation techniques such as self-hypnosis, biofeedback, or autogenic training.

5. Get high-quality sleep

Get plenty of restful sleep. It’s during sleep that your brain consolidates memories, repairs itself, and grows new brain cells.

6. Utilize Therapy

Learn about the ways in which you stress yourself out and how to better manage or respond to stress.